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Synthesis method and application of triphenylphosphine

    Triphenylphosphine, CAS No. : 603-35-0 Molecular formula: C18H15P, rhodium phosphine complex catalyst for the basic raw material, has a broad use in domestic petrochemical industry. Triphenylphosphine is also used in pharmaceutical industry, organic synthesis, analysis and other fields. Triphenylphosphine can also be used as dye process brightener, polymer polymerization, color film display antioxidant, poly epoxidation stabilizer, but also as an analytical reagent.

    Synthesis method of triphenylphosphine
    Grignard’s reagent was prepared with 34.1 g (0.22 mol) bromobenzene, 5.2 g (0.21 g) atomic magnesium and 108 ml anhydrous diethyl ether in dry gas. The obtained phenyl magnesium bromide was stored in inert gas, stirred and cooled in an ice bath. 6.0 g (0.044 mol) of phosphorus trichloride and 35 ml of diethyl ether solution were added slowly (15~20 min). Process the mixture slowly in a solution of 11 ml concentrated hydrochloric acid and 30 ml water. The ether layer is separated and the water layer is extracted with ether. After the ether solution was combined, it was distilled under atmospheric hydrogen until the residual temperature in the distillation container reached 285℃ and the residue was recrystallized with ethanol for a second time. The white triphenylphosphine was obtained at 8.7 g (76%) and the melting point was 79.5℃.

    Uses of triphenylphosphine
    Triphenylphosphine is the basic raw material of rhodium phosphine complex catalyst, which has broad application in domestic petrochemical industry. Triphenylphosphine is also used in pharmaceutical industry, organic synthesis, analysis and other fields. Triphenylphosphine can also be used as dye process brightener, polymer polymerization, color film display antioxidant, poly epoxidation stabilizer, but also as an analytical reagent.

    1. Used in organic synthesis, polymerization initiator, antibiotic drug chlorlincomycin raw material, organic trace analysis of phosphorus standard sample.
    2. Palladium, iridium, rhodium, nickel complex catalyst, Wfttig reagent, triphenylphosphine dihalide deoxidation (n-oxide pyridine, nitrobenzene, hydroperoxide), desulfurization, debromination reagent. The a-bromonitro compound is formed into nitrile. A-ketonaldehydes and β -ketonates are synthesized by reacting with adipose diazo compounds. Beckmann rearrangement. Dequaternary ammonium of pyridine bell salt. It is used in some synthesis with bromo-iodine, tetrachloro (bromo-carbon), n-butadiene bromide imide, etc.
    3. Triphenylphosphine is a fairly common reducing agent, and in most cases the reaction is driven by the formation of triphenylphosphine oxide (a thermodynamically favorable reaction). In addition, triphenylphosphine is widely used as a ligand in metal catalysts.

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