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Preparation of lentinus edodes polysaccharide complex supported by plateau catechuic acid

    Lentinus edodes polysaccharide is water-soluble and electrically neutral, so it is more suitable for cosmetic applications. It has excellent anti-aging effects, can smooth out fine wrinkles and improve skin texture. Endows the product with good transdermal absorption performance, and can be used as the release carrier of active ingredients to give the skin a silk-like moist and smooth touch.

    Highland catechuic acid, also known as 3, 4-dihydroxyphenylacetic acid, exists in the form of free or polymerization in plants and is one of the main phenolic acids. It is also an important biochemical detection reagent and has been very active in the research and application of biochemistry [1]. Compounds with this structure show more physiological activities, such as antioxidant, antibacterial, antiviral, liver protection, treatment of central nervous diseases, inhibition of cyclooxygenase and esteroxygenase activities.

    Acne and other skin problems can be caused by inflammation. By suppressing inflammation and improving skin condition, acne and skin aging can be effectively improved. In skin care products, multiple combinations are often needed to create synergies that suppress inflammation and improve skin.

    One of the technical problems to be solved in this paper is to provide a preparation method and application of a new type of lentinus edodes polysaccharide complex supported by plateau catechuic acid. The purpose is to integrate lentinus edodes polysaccharide and plateau catechuic acid, so that the two can be used synergistically in the research and development of skin care products and drugs.

    To achieve the above purposes, the invention adopts the following technical scheme. The plateau catechuic acid of the invention is loaded with lentinus edodes polysaccharide complex, including raw materials by weight percentage: Lentinus edodes polysaccharide, the content of 80-99%; High altitude catechin acid, 1% – 20%.

    Further, the lentinan mushroom polysaccharide, also known as lentinan, CAS :37339-90-5, molecular weight: 1152.9995, gray powder.

    Further, the plateau catechin acid, also known as 3, 4-dihydroxyphenylacetic acid, CAS :102-32-9, light gray powder.

    A preparation method of the above-mentioned plateau catechuic acid loaded lentinus edodes polysaccharide complex (extracted after biological fermentation) includes the following steps:

    With fresh green tea as the main, sucrose, peptone, potassium hydrogen phosphate as the auxiliary, according to the weight ratio of tea and water 1:1 tea and water fully mixed; After sterilization at 121℃ for 20-30 minutes, tea culture medium was obtained. Co-culture the tea medium with lentinus edodes mycelium; The fermentation products of Lentinus edodes mycelium were separated by water extraction and alcohol precipitation, and the lentinus edodes polysaccharide complex was finally refined.

    Further, the variety of mushroom is not limited to a single variety of mushroom.

    A preparation method (chemical synthesis route) for the above-mentioned plateau catechuic acid loaded lentinus edodes polysaccharide complex comprises the following steps:

    Plateau catechuic acid and lentinan were mixed in deionized water in a corresponding proportion. DCC (dicyclohexyl carbon diimine) equivalent to plateau catechuic acid was added as a condensation agent; Stirring reaction at room temperature for 24h; Dialysis for 24 hours to remove excess DCC and unreacted plateau catechin acid; Finally, the corresponding lentinus edodes polysaccharide complex was obtained by freeze drying.

    The lentinus edodes polysaccharide complex obtained by the above two preparation methods is the same product.

    Further, mainly in the form of water-based pastes or gels or liquids, such as water-based liquids.

    Application of plateau catechuic acid-loaded Lentinus edodes polysaccharide complex, the plateau catechuic acid-loaded Lentinus edodes polysaccharide complex was prepared as aqueous lotion, oil-in-water or oil-in-water emulsion, oil or oil. Alcohol lotion, anionic or non-ionic amphiphilic cystic dispersion, aqueous gel, water. Alcohol gel, alcohol gel or oil. Alcohol gel, solid rod or aerosol.

    Application of plateau catechuic acid loaded lentinus edodes polysaccharide complex, plateau catechuic acid loaded Lentinus edodes polysaccharide complex for anti-inflammatory, promote fiber cell proliferation, skin care preparation.

    Further, the dosage form is any clinically acceptable dosage form.

    Further, the plateau catechuic acid-loaded lentinus edodes polysaccharide complex is the only active ingredient of the anti-inflammatory, promoting fiber cell proliferation or skin care, or the complex is combined with other substances to prepare the anti-inflammatory, promoting fiber cell proliferation or skin care preparation.

    Compared with the prior art, the preparation process of the plateau catechuic acid loaded lentinan polysaccharide complex of the invention can greatly improve the stability of the plateau catechuic acid and realize slow release in cosmetics.

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