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A method for synthesizing d-glucosamine sodium sulfate salt

    The invention relates to A preparation method for synthesizing d-glucosamine sodium sulfate salt, which includes the following steps A, dissolving in A reactor, adding water, heating to A temperature of 70. C 80°C, add sodium sulfate under the condition of stirring, after its dissolution, reduce the temperature to 60°C 65°C, add D-glucosamine hydrochloride, continue stirring, after its dissolution, increase the solution temperature to 65°C 75°C, add organic solvent, reduce the temperature to 15°C 25°C, continue stirring for 10 15 hours, Make all materials react fully in the reactor; B, crystallization of the material completed by the above reaction cooling to 0° C-10 °C, crystallization under stirring conditions for 90 120 minutes, and then in a centrifuge after centrifuge dehydration white crystals; C, drying The white crystals after centrifugation are dried under the vacuum condition of 55°C 65°C to synthesize D-glucosamine sodium sulfate salt. Beneficial effects The preparation method for synthesizing D-glucosamine sodium sulfate salt of the invention has the advantages of simple technological process, low cost and beneficial to industrial production; In addition, the synthetic D-glucosamine sodium sulfate salt prepared by the preparation method of the invention has high purity, fewer impurities and good efficacy.

    The specific embodiments are combined with the specific embodiments below
    This invention further illustrate the implementation of case 1 A synthetic D – glucosamine sodium sulfate salt preparation methods, including the following steps, dissolved in A reactor with water, heated to A temperature of 70 ° C, stir in under the condition of adding sodium sulfate, it dissolves temperature dropped to 60 ° C, join D – glucosamine hydrochloride, continue to stir, After it is dissolved, the solution temperature is raised to 65°C, organic solvent is added, the temperature is lowered to 15°C, and stirring is continued for 10 hours to make all materials fully react in the reactor; B. Crystallization The material completed by the above reaction is cooled to 0°C, and crystallized for 90 minutes under stirring conditions, and then centrifuged and dehydrated in a centrifuge to obtain white crystals; C. Drying The white crystals after centrifugation are dried in a vacuum at 55°C to obtain the synthesis of D-glucosamine sodium sulfate salt. Example A synthetic 2 D – glucosamine sodium sulfate salt preparation methods, including the following steps, dissolved in A reactor with water, heated to A temperature of 80 ° C, stir in under the condition of adding sodium sulfate, it dissolves temperature down to 65 ° C, add D – glucosamine hydrochloride, continue to stir, it dissolves the solution temperature rise to 75 ° C, Add organic solvent, drop temperature to 25°C, continue stirring for 15 hours to make all materials fully react in the reactor; B. Crystallization The material completed by the above reaction is cooled to -10°C, and crystallized under stirring conditions for 120 minutes, and then centrifuged and dehydrated in a centrifuge to obtain white crystals; C. Drying The white crystals after centrifugation are dried in the vacuum condition of 65°C to obtain the synthesis of D-glucosamine sodium sulfate salt. A synthetic implementation example 3 D – glucosamine sodium sulfate salt preparation methods, including the following steps, dissolved in A reactor with water, heated to A temperature of 75 ° C, stir in under the condition of adding sodium sulfate, it dissolves temperature down to 62 ° C, add D – glucosamine hydrochloride, continue to stir, it dissolves the solution temperature rise to 70 ° C, Add organic solvent, drop temperature to 20°C, and stir for 12 hours to make all materials fully react in the reactor. B. Crystallization The material completed by the above reaction is cooled to _5°C, and crystallized under stirring conditions for 105 minutes, and then centrifuged and dehydrated in a centrifuge to obtain white crystals; C. Drying The white crystals after centrifugation are dried in a vacuum at 60°C to obtain the synthesis of D-glucosamine sodium sulfate salt.

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